Programming a topologically constrained DNA nanostructure into a sensor
نویسندگان
چکیده
منابع مشابه
Programming a topologically constrained DNA nanostructure into a sensor
Many rationally engineered DNA nanostructures use mechanically interlocked topologies to connect individual DNA components, and their physical connectivity is achieved through the formation of a strong linking duplex. The existence of such a structural element also poses a significant topological constraint on functions of component rings. Herein, we hypothesize and confirm that DNA catenanes w...
متن کاملVoltage Stability Constrained OPF Using A Bilevel Programming Technique
This paper presents a voltage stability constrained optimal power flow that is expressed via a bilevel programming framework. The inner objective function is dedicated for maximizing voltage stability margin while the outer objective function is focused on minimization of total production cost of thermal units. The original two stage problem is converted to a single level optimization problem v...
متن کاملTopologically Constrained Isometric Embedding
We present a new algorithm for nonlinear dimensionality reduction that consistently uses global information, which enables understanding the intrinsic geometry of non-convex manifolds. Compared to methods that consider only local information, our method appears to be more robust to noise. We demonstrate the performance of our algorithm and compare it to state-of-the-art methods on synthetic a...
متن کاملDynamical Scaling and Phase Coexistence in Topologically Constrained DNA Melting.
There is a long-standing experimental observation that the melting of topologically constrained DNA, such as circular closed plasmids, is less abrupt than that of linear molecules. This finding points to an important role of topology in the physics of DNA denaturation, which is, however, poorly understood. Here, we shed light on this issue by combining large-scale Brownian dynamics simulations ...
متن کاملPrediction of Significant Cruciform Structures from Sequence in Topologically Constrained DNA - A Probabilistic Modelling Approach
Sequence-dependent secondary DNA structures, such as cruciform or triplex DNA, are implicated in regulation of gene transcription and other important biological processes at the molecular level. Sequences capable of forming these structures can readily be identified in entire genomes by appropriate searching techniques. However, not every DNA segment containing the proper sequence has equal pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms12074